If you prefer, you can also pay in person with cash. If you book online, you can choose to pay with a debit card or credit card on the Greyhound app or website. Booking in advance, whether on the app or website, is the best way to get the most affordable bus travel. The Los Angeles to Las Vegas bus starts from $20.99. How much is the Los Angeles to Las Vegas bus and how can I buy a ticket? The quickest trip with Greyhound takes 4 hours 45 minutes and you can expect a minimum of one stop. The bus trip from Los Angeles to Las Vegas is about 264 miles long. How long does the bus from Los Angeles to Las Vegas take with Greyhound?